Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates

• Main Authors: Yuta Suzuki (Author), Takayuki Miyazaki (Author), Hiroki Muto (Author), Kenji Kubara (Author), Yohei Mukai (Author), Ryuji Watari (Author), Shinya Sato (Author), Keita Kondo (Author), Shin-ichi Tsukumo (Author), Koji Yasutomo (Author), Masashi Ito (Author), Kappei Tsukahara (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

mRNA and lipid nanoparticles have emerged as powerful systems for the preparation of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The emergence of novel variants or the necessity of cold chain logistics for approved mRNA vaccines undermines the investigati...