Inclisiran for the treatment of hypercholesterolaemia

• Main Authors: Joel C Marrs (Author), Sarah L Anderson (Author)
• פורמט: ספר
• יצא לאור: BioExcel Publishing Ltd, 2024-11-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Inclisiran is a synthetic small interfering RNA (siRNA) that inhibits the production of proprotein convertase subtilisin/ kexin 9 (PCSK9) in hepatocytes by silencing the translation of PCSK9 mRNA. The result of this mechanism is a decrease in PCSK9 synthesis resulting in decreased degradation of the...