Decreasing fluconazole susceptibility of clinical South African Cryptococcus neoformans isolates over a decade.

• Main Authors: Serisha D Naicker (Author), Ruth S Mpembe (Author), Tsidiso G Maphanga (Author), Thokozile G Zulu (Author), Daniel Desanto (Author), Jeannette Wadula (Author), Nomonde Mvelase (Author), Caroline Maluleka (Author), Kessendri Reddy (Author), Halima Dawood (Author), Motlatji Maloba (Author), Nelesh P Govender (Author), for GERMS-SA (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Fluconazole is used in combination with amphotericin B for induction treatment of cryptococcal meningitis and as monotherapy for consolidation and maintenance treatment. More than 90% of isolates from first episodes of cryptococcal disease had a fluconazole minimum inh...