Effect of tramadol on metamizol pharmacokinetics and pharmacodynamics after single and repeated administrations in arthritic rats

• Główni autorzy: Luis Alfonso Moreno-Rocha (Autor), Francisco Javier López-Muñoz (Autor), José Raúl Medina-López (Autor), Adriana Miriam Domínguez-Ramírez (Autor)
• Format: Książka
• Wydane: Elsevier, 2016-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Combined administration of certain doses of opioid compounds with a non-steroidal anti-inflammatory drug can produce additive or supra-additive effects while reducing unwanted effects. We have recently reported that co-administration of metamizol with tramadol produces antinociceptive effect potenti...