Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFRL858R/T790M inhibitors

• প্রধান লেখক: Jianfang Fu (লেখক), Jie Yu (লেখক), Xiang Zhang (লেখক), Yaoyao Chang (লেখক), Hongze Fan (লেখক), Mengzhen Dong (লেখক), Mengjia Li (লেখক), Yue Liu (লেখক), Jinxing Hu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

EGFR mutations have been identified in 20,000 reported NSCLC (non-small cell lung cancer) samples, and exon 19 deletions and L858R mutations at position 21, known as "classical" mutations, account for 85-90% of the total EGFR (epidermal growth factor receptor) mutations. In this paper, two...