Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFRL858R/T790M inhibitors

EGFR mutations have been identified in 20,000 reported NSCLC (non-small cell lung cancer) samples, and exon 19 deletions and L858R mutations at position 21, known as "classical" mutations, account for 85-90% of the total EGFR (epidermal growth factor receptor) mutations. In this paper, two...

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Váldodahkkit: Jianfang Fu (Dahkki), Jie Yu (Dahkki), Xiang Zhang (Dahkki), Yaoyao Chang (Dahkki), Hongze Fan (Dahkki), Mengzhen Dong (Dahkki), Mengjia Li (Dahkki), Yue Liu (Dahkki), Jinxing Hu (Dahkki)
Materiálatiipa: Girji
Almmustuhtton: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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