Association Between Changes in BLyS Levels and the Composition of B and T Cell Compartments in Patients With Refractory Systemic Lupus Erythematosus Treated With Belimumab

• Κύριοι συγγραφείς: Francesca Regola (Συγγραφέας), Silvia Piantoni (Συγγραφέας), Torsten Lowin (Συγγραφέας), Silvia Archetti (Συγγραφέας), Rossella Reggia (Συγγραφέας), Rajesh Kumar (Συγγραφέας), Franco Franceschini (Συγγραφέας), Paolo Airò (Συγγραφέας), Angela Tincani (Συγγραφέας), Laura Andreoli (Συγγραφέας), Georg Pongratz (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Introduction: Belimumab is a monoclonal antibody against soluble BLyS used for treatment of refractory Systemic Lupus Erythematosus (SLE). Although B cells are the main target of this therapy, a BLyS-dependent T cell activation pathway has also been demonstrated. The aim of the study is to analyze B...