Association Between Changes in BLyS Levels and the Composition of B and T Cell Compartments in Patients With Refractory Systemic Lupus Erythematosus Treated With Belimumab

• Main Authors: Francesca Regola (Author), Silvia Piantoni (Author), Torsten Lowin (Author), Silvia Archetti (Author), Rossella Reggia (Author), Rajesh Kumar (Author), Franco Franceschini (Author), Paolo Airò (Author), Angela Tincani (Author), Laura Andreoli (Author), Georg Pongratz (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Introduction: Belimumab is a monoclonal antibody against soluble BLyS used for treatment of refractory Systemic Lupus Erythematosus (SLE). Although B cells are the main target of this therapy, a BLyS-dependent T cell activation pathway has also been demonstrated. The aim of the study is to analyze B...