Efficient Gene Delivery to Pig Airway Epithelia and Submucosal Glands Using Helper-Dependent Adenoviral Vectors

• Main Authors: Huibi Cao (Author), Tiago N Machuca (Author), Jonathan C Yeung (Author), Jing Wu (Author), Kai Du (Author), Cathleen Duan (Author), Kohei Hashimoto (Author), Virginia Linacre (Author), Allan L Coates (Author), Kitty Leung (Author), Jian Wang (Author), Herman Yeger (Author), Ernest Cutz (Author), Mingyao Liu (Author), Shaf Keshavjee (Author), Jim Hu (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Airway gene delivery is a promising strategy to treat patients with life-threatening lung diseases such as cystic fibrosis (CF). However, this strategy has to be evaluated in large animal preclinical studies in order to translate it to human applications. Because of anatomic and physiological simila...