Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer

• Auteurs principaux: Fabiana Sélos Guerra (Auteur), Daniel Alencar Rodrigues (Auteur), Carlos Alberto Manssour Fraga (Auteur), Patricia Dias Fernandes (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background: Prostate cancer is the second most frequently diagnosed malignancy worldwide. Here, the cytotoxic and antimetastatic effects of a new HDAC6/8 inhibitor, LASSBio-1911, and a new dual-PI3K/HDAC6 inhibitor, LASSBio-2208, were evaluated against PC3 prostate cancer cell line. Methods: A MTT a...