Multiscale model of hepatitis C virus dynamics in plasma and liver following combination therapy

• Main Authors: Xavier Woot de Trixhe (Author), Wojciech Krzyzanski (Author), An Vermeulen (Author), Juan José Perez‐Ruixo (Author)
• Format: Knjiga
• Izdano: Wiley, 2021-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract This work explores the application of a physiologically structured population (PSP) framework in modeling hepatitis C virus (HCV) kinetics. To do so, a model was developed for the viral RNA load in plasma and liver as observed in 15 patients treated with a combination therapy of pegylated i...