Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

• Main Authors: Siyoung Lee (Author), Youngmin Lee (Author), Kwangwon Hong (Author), Jaewoo Hong (Author), Suyoung Bae (Author), Jida Choi (Author), Hyunjhung Jhun (Author), Areum Kwak (Author), Eunsom Kim (Author), Seunghyun Jo (Author), Charles A. Dinarello (Author), Soohyun Kim (Author)
• Format: Book
• Published: BMC, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3. Here, we expressed recombinant AAT by fusing the intact AAT gene to the constan...