Differential impact of cysteine cathepsins on genetic mouse models of de novo carcinogenesis: cathepsin B as emerging therapeutic target

• Main Authors: Thomas eReinheckel (Author), Christoph ePeters (Author), Achim eKrüger (Author), Boris eTurk (Author), Olga eVasiljeva (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets. Until recently, the contribution of individual cathepsins to tumorigenesis and tumor progre...