Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway

• Main Authors: Zong Chen (Author), Yong Ding (Author), Ying Zeng (Author), Xue-Ping Zhang (Author), Jian-Yan Chen (Author)
• Format: Bog
• Udgivet: BMC, 2022-03-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Abstract Background Propofol and dexmedetomidine (DEX) are widely used in general anesthesia, and exert toxic and protective effects on hippocampal neurons, respectively. The study sought to investigate the molecular mechanisms of DEX-mediated neuroprotection against propofol-induced hippocampal neu...