A network paradigm predicts drug synergistic effects using downstream protein-protein interactions

• Главные авторы: Jennifer L. Wilson (Автор), Ethan Steinberg (Автор), Rebecca Racz (Автор), Russ B. Altman (Автор), Nigam Shah (Автор), Kevin Grimes (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2022-11-01T00:00:00Z.
• Предметы: article
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Abstract In some cases, drug combinations affect adverse outcome phenotypes by binding the same protein; however, drug‐binding proteins are associated through protein-protein interaction (PPI) networks within the cell, suggesting that drug phenotypes may result from long‐range network effects. We fi...