A network paradigm predicts drug synergistic effects using downstream protein-protein interactions

Abstract In some cases, drug combinations affect adverse outcome phenotypes by binding the same protein; however, drug‐binding proteins are associated through protein-protein interaction (PPI) networks within the cell, suggesting that drug phenotypes may result from long‐range network effects. We fi...

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Main Authors: Jennifer L. Wilson (Author), Ethan Steinberg (Author), Rebecca Racz (Author), Russ B. Altman (Author), Nigam Shah (Author), Kevin Grimes (Author)
Format: Book
Published: Wiley, 2022-11-01T00:00:00Z.
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