Ionic co-aggregates (ICAs) based oral drug delivery: Solubilization and permeability improvement

• Main Authors: Xianzi Zheng (Author), Zhezheng Fang (Author), Weizi Huang (Author), Jianping Qi (Author), Xiaochun Dong (Author), Weili Zhao (Author), Wei Wu (Author), Yi Lu (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to the overwhelming percentage of poorly water-soluble drugs, pharmaceutical industry is in urgent need of efficient approaches for solubilization and permeability improvement. Salts consisting of lipophilic fatty acid anions and hydrophilic choline cations are found to be surface active and abl...