Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease

• Main Authors: Maurício dos Santos Pereira (Author), Gabriel Henrique Dias Abreu (Author), Jeremy Rocca (Author), Sabah Hamadat (Author), Rita Raisman-Vozari (Author), Patrick Pierre Michel (Author), Elaine Del Bel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our present objective was to better characterize the mechanisms that regulate striatal neuroinflammation in mice developing L-DOPA-induced dyskinesia (LID). For that, we used 6-hydroxydopamine (6-OHDA)-lesioned mice rendered dyskinetic by repeated intraperitoneal injections of 3,4-dihydroxyphenyl-L-...