Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease

• Autores principales: Maurício dos Santos Pereira (Autor), Gabriel Henrique Dias Abreu (Autor), Jeremy Rocca (Autor), Sabah Hamadat (Autor), Rita Raisman-Vozari (Autor), Patrick Pierre Michel (Autor), Elaine Del Bel (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Our present objective was to better characterize the mechanisms that regulate striatal neuroinflammation in mice developing L-DOPA-induced dyskinesia (LID). For that, we used 6-hydroxydopamine (6-OHDA)-lesioned mice rendered dyskinetic by repeated intraperitoneal injections of 3,4-dihydroxyphenyl-L-...