Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

• Main Authors: Angela Cirigliano (Author), Antonia Amelina (Author), Beatrice Biferali (Author), Alberto Macone (Author), Chiara Mozzetta (Author), Michele Maria Bianchi (Author), Mattia Mori (Author), Bruno Botta (Author), Elah Pick (Author), Rodolfo Negri (Author), Teresa Rinaldi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medical use, yet statins treatment could induce side e...