Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

• मुख्य लेखकों: Angela Cirigliano (लेखक), Antonia Amelina (लेखक), Beatrice Biferali (लेखक), Alberto Macone (लेखक), Chiara Mozzetta (लेखक), Michele Maria Bianchi (लेखक), Mattia Mori (लेखक), Bruno Botta (लेखक), Elah Pick (लेखक), Rodolfo Negri (लेखक), Teresa Rinaldi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medical use, yet statins treatment could induce side e...