Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators

Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators

The study investigated the inhibitory activity of protocetraric and salazinic acids against SARS-CoV-2 3CL<sup>pro</sup>. The kinetic parameters were determined by microtiter plate-reading fluorimeter using a fluorogenic substrate. The cytotoxic activity was tested on murine Sertoli TM4...

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Main Authors: Lorenza Fagnani (Author), Lisaurora Nazzicone (Author), Pierangelo Bellio (Author), Nicola Franceschini (Author), Donatella Tondi (Author), Andrea Verri (Author), Sabrina Petricca (Author), Roberto Iorio (Author), Gianfranco Amicosante (Author), Mariagrazia Perilli (Author), Giuseppe Celenza (Author)
Format: Book
Published: MDPI AG, 2022-06-01T00:00:00Z.
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3rd Floor Main Library

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