Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators

• Main Authors: Lorenza Fagnani (Author), Lisaurora Nazzicone (Author), Pierangelo Bellio (Author), Nicola Franceschini (Author), Donatella Tondi (Author), Andrea Verri (Author), Sabrina Petricca (Author), Roberto Iorio (Author), Gianfranco Amicosante (Author), Mariagrazia Perilli (Author), Giuseppe Celenza (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study investigated the inhibitory activity of protocetraric and salazinic acids against SARS-CoV-2 3CL^pro. The kinetic parameters were determined by microtiter plate-reading fluorimeter using a fluorogenic substrate. The cytotoxic activity was tested on murine Sertoli TM4...