Cover Image

Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators

The study investigated the inhibitory activity of protocetraric and salazinic acids against SARS-CoV-2 3CL<sup>pro</sup>. The kinetic parameters were determined by microtiter plate-reading fluorimeter using a fluorogenic substrate. The cytotoxic activity was tested on murine Sertoli TM4...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lorenza Fagnani (Author), Lisaurora Nazzicone (Author), Pierangelo Bellio (Author), Nicola Franceschini (Author), Donatella Tondi (Author), Andrea Verri (Author), Sabrina Petricca (Author), Roberto Iorio (Author), Gianfranco Amicosante (Author), Mariagrazia Perilli (Author), Giuseppe Celenza (Author)
Format:	Book
Published:	MDPI AG, 2022-06-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Cyclic and Acyclic Amine Oxide Alkyl Derivatives as Potential Adjuvants in Antimicrobial Chemotherapy against Methicillin-Resistant <i>Staphylococcus aureus</i> with an MDR Profile
by: Lorenza Fagnani, et al.
Published: (2021)

Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly
by: Jiafan Yang, et al.
Published: (2023)

Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation
by: Roberto Iorio, et al.
Published: (2022)

Phenylboronic Acids Probing Molecular Recognition against Class A and Class C β-lactamases
by: Pasquale Linciano, et al.
Published: (2019)

4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-<i>β</i>-Lactamases
by: Pasquale Linciano, et al.
Published: (2020)

Whole-Genome Sequencing of ST2 <i>A. baumannii</i> Causing Bloodstream Infections in COVID-19 Patients
by: Sabrina Cherubini, et al.
Published: (2022)

Oxidative Stress, Cytotoxic and Inflammatory Effects of Azoles Combinatorial Mixtures in Sertoli TM4 Cells
by: Sabrina Petricca, et al.
Published: (2023)

Evaluating the In Vitro Activity of Depsidones from Usnea subfloridana Stirton as Key Enzymes Involved in Inflammation and Gout
by: Thanh-Trung Nguyen, et al.
Published: (2021)

Novel Targets and Mechanisms in Antimicrobial Drug Discovery
by: Donatella Tondi
Published: (2021)

Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer's disease
by: Meixia Yang, et al.
Published: (2024)

The depsidones from marine sponge-derived fungus Aspergillus unguis IB151 as an anti-MRSA agent: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies
by: Dian Handayani, et al.
Published: (2023)

Hepatoprotective activity of depsidone enriched Cladonia rangiferina extract against alcohol-induced hepatotoxicity targeting cytochrome P450 2E1 induced oxidative damage
by: Ila Shukla, et al.
Published: (2020)

Examination of third molar Missing in skeletal Cl I , Cl II in Tehran dental school patients during
by: Chalipa J, et al.
Published: (2010)

Success in the treatment of the Skeletal Cl III Cases
by: Mirzen Arat, et al.
Published: (1988)

Cephalometric Study of Iraqi Adult Subjects with Cl I and Cl III Skeletal Relationships and Their Effects on Masseter Muscle Thickness by Using Ultrasonography
by: Hibah ER Berum, et al.
Published: (2016)

The effect of NaCl 0.9% and NaCl 0.45% on sodium, chloride, and acid-base balance in a PICU population
by: Helena Isabel Almeida, et al.
Published: (2015)

The effect of NaCl 0.9% and NaCl 0.45% on sodium, chloride, and acid‐base balance in a PICU population
by: Helena Isabel Almeida, et al.
Published: (2015)

The effect of NaCl 0.9% and NaCl 0.45% on sodium, chloride, and acid-base balance in a PICU population
by: Helena Isabel Almeida, et al.
Published: (2015)

KONVERSI LIGNOSELULOSA JERAMI JAGUNG (CORN STOVER) MENJADI 5-HIDROKSIMETIL-2-FURFURAL (HMF) DALAM MEDIA ZnCl2 DENGAN CO-CATALYST ZEOLIT, CrCl3, DAN DMA-LiCl
by: A'dawiyah, Siti Robiah
Published: (2014)

In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors
by: Saipul Maulana, et al.
Published: (2023)

Success in The Treatment of The Skeletal Cl III Cases (I)
by: Ayşegül Köklü, et al.
Published: (1988)

UAI case: An uCASE-CL model implementation
by: Nicolas Battaglia, et al.
Published: (2019)

Plant Products as Inhibitors of Coronavirus 3CL Protease
by: Anirban Mandal, et al.
Published: (2021)

A missense mutation accelerating the gating of the lysosomal Cl−/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle
by: Arnaud Sartelet, et al.
Published: (2014)

Synthesis, Drug Release, and Antibacterial Properties of Novel Dendritic CHX-SrCl<sub>2</sub> and CHX-ZnCl<sub>2</sub> Particles
by: Rui Sun, et al.
Published: (2021)

Punch, or the London Charivari, Vol. CL, April 26, 1916
by: Various; Seaman, Owen, 1861-1936 [Editor]

Regulation of ClC-2 Activity by SPAK and OSR1
by: Jamshed Warsi, et al.
Published: (2014)

Inhibition of SARS-CoV 3CL protease by flavonoids
by: Seri Jo, et al.
Published: (2020)

Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?
by: Eleonora Gianquinto, et al.
Published: (2020)

Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis.
by: Luz Estella Mesa, et al.
Published: (2020)

Morphometric analysis of nasal profile in patients with Cl II skeletal malocclusion
by: Amin Shirvani, et al.
Published: (2013)

LanCL2 Implicates in Testicular Redox Homeostasis and Acrosomal Maturation
by: Yanling Zhao, et al.
Published: (2024)

ANTIBIOTIC-ASSOCIATED DIARRHEA AND CL. DIFFICILE-INFECTION IN CHILDREN: RISK FACTORS
by: L. N. Mazankova, et al.
Published: (2015)

Aquios CL flow cytometer performance in the automated quantification of lymphocyte subpopulations
by: Laiz C. Bento, et al.

Equidade e regionalização da saúde na contracorrente
by: Eduardo Fagnani
Published: (2019)

KONVERSI SELULOSA DARI BIOMASSA JERAMI PADI MENJADI 5-HIDROKSIMETILFURFURAL ( HMF ) SEBAGAI PREKURSOR BIOFUEL MENGGUNAKAN MEDIA ZnCl2 DAN KATALIS CrCl3
by: Lestari, Annisa Dwi
Published: (2013)

KONVERSI LIGNOSELULOSA TANDAN PISANG MENJADI 5-HIDROKSIMETIL-2-FURFURAL (HMF) : OPTIMASI KOMPOSISI ZnCl2 DAN CrCl3 SERTA EKSPLORASI METODE PEMISAHAN
by: Siswara, Indra Melta
Published: (2015)

PENGGUNAAN RADIASI MICROWAVE PADA KONVERSI SELULOSA MENJADI 5- IDROKSIMETILFURFURAL (HMF) DARI BIOMASSA JERAMI PADI DENGAN MEDIA ZnCl2 DAN KATALIS CrCl3
by: Dikarinawati, Henny
Published: (2014)

Comparison of Microleakage in Composite Cl II Restorations by Open Sandwich and Snowplow Technique
by: Abdolrahim Davari, et al.
Published: (2022)

Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis
by: Saeed Alshahrani, et al.
Published: (2017)