Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy

• Main Authors: Nuoyan Zheng (Author), Bing Wang (Author), Jinjin Fan (Author), Ning Luo (Author), Qingyu Kong (Author), Hongjian Ye (Author), Jiqin Zhang (Author), Hongyan Ming (Author), Xueqing Yu (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The roles of pDC and IFN-α have not been well defined in IgA nephropathy (IgAN). In this study, we investigated the abundance of pDCs and IFN-α in IgAN patients and the response of peripheral blood mononuclear cells (PBMCs) after stimulation of the pDC-preferred TLR9 ligand CpG2216. The effects of I...