Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity

• Main Authors: Dalia Ali (Author), Elna P. Chalisserry (Author), Muthurangan Manikandan (Author), Rimi Hamam (Author), Musaad Alfayez (Author), Moustapha Kassem (Author), Abdullah Aldahmash (Author), Nehad M. Alajez (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone marrow mesenchymal stem cells (BMSCs) are adult multipotent stem cells that can differentiate into mesodermal lineage cells, including adipocytes and osteoblasts. However, the epigenetic mechanisms governing the lineage-specific commitment of BMSCs into adipocytes or osteoblasts are under inves...