The prevalence and antifolate drug resistance profiles of Plasmodium falciparum in study participants randomized to discontinue or continue cotrimoxazole prophylaxis.

• Main Authors: Dennis W Juma (Author), Peninah Muiruri (Author), Krista Yuhas (Author), Grace John-Stewart (Author), Ronald Ottichilo (Author), John Waitumbi (Author), Benson Singa (Author), Christina Polyak (Author), Edwin Kamau (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OBJECTIVE:Cotrimoxazole prevents opportunistic infections including falciparum malaria in HIV-infected individuals but there are concerns of cross-resistance to other antifolate drugs such as sulphadoxine-pyrimethamine (SP). In this study, we investigated the prevalence of antifolate-resistance muta...