Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway

• Main Authors: Xianguo Ren (Author), Yun Bo (Author), Junting Fan (Author), Maosheng Chen (Author), Daliang Xu (Author), Yang Dong (Author), Haowei He (Author), Xianzhi Ren (Author), Rong Qu (Author), Yulian Jin (Author), Weihong Zhao (Author), Changliang Xu (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10 mg/kg) via the tail vein. Renal function was an...