PLGA Microspheres of hGH of Preserved Native State Prepared Using a Self-Regulated Process

• Main Authors: Jebun Nessa Diana (Author), Ying Tao (Author), Qiran Du (Author), Meng Wang (Author), Chinta Uday Kumar (Author), Fei Wu (Author), Tuo Jin (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The challenges of formulating recombinant human growth hormone (rhGH) into sustained-release polymeric microspheres include two mutual causal factors, protein denaturing by the formulation process and severe initial burst release related with relative high dose. The stabilizers to protect the protei...