Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

• Main Authors: Xiaofan Sun (Author), Lisha Zhou (Author), Yi Wang (Author), Guoliang Deng (Author), Xinran Cao (Author), Bowen Ke (Author), Xiaoqi Wu (Author), Yanhong Gu (Author), Haibo Cheng (Author), Qiang Xu (Author), Qianming Du (Author), Hongqi Chen (Author), Yang Sun (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to immunotherapy. Cannabidiol (CBD) is a non-psychoactive natural active ingredient from the cannabis plant that has various pharmacological effects, including neuroprotective, antiemetic, anti-in...