Dissemination of Orientia tsutsugamushi and inflammatory responses in a murine model of scrub typhus.

• Main Authors: Christian A Keller (Author), Matthias Hauptmann (Author), Julia Kolbaum (Author), Mohammad Gharaibeh (Author), Melanie Neumann (Author), Markus Glatzel (Author), Bernhard Fleischer (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Central aspects in the pathogenesis of scrub typhus, an infection caused by Orientia (O.) tsutsugamushi, have remained obscure. Its organ and cellular tropism are poorly understood. The purpose of this study was to analyze the kinetics of bacterial dissemination and associated inflammatory responses...