Case report: Effectiveness of sirolimus in a de novo FAS mutation leading to autoimmune lymphoproliferative syndrome-FAS and elevated DNT/Treg ratio

• Autori principali: Hao Gu (Autore), Zhenping Chen (Autore), Jie Ma (Autore), Jingyao Ma (Autore), Lingling Fu (Autore), Rui Zhang (Autore), Tianyou Wang (Autore), Runhui Wu (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

BackgroundThe autoimmune lymphoproliferative syndrome (ALPS) is a rare disease characterized by defective function of the FAS death receptor, which results in chronic, non-malignant lymphoproliferation and autoimmunity accompanied by elevated numbers of double-negative (DN) T cells (T-cell receptor...