Case report: Effectiveness of sirolimus in a de novo FAS mutation leading to autoimmune lymphoproliferative syndrome-FAS and elevated DNT/Treg ratio

• Main Authors: Hao Gu (Author), Zhenping Chen (Author), Jie Ma (Author), Jingyao Ma (Author), Lingling Fu (Author), Rui Zhang (Author), Tianyou Wang (Author), Runhui Wu (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BackgroundThe autoimmune lymphoproliferative syndrome (ALPS) is a rare disease characterized by defective function of the FAS death receptor, which results in chronic, non-malignant lymphoproliferation and autoimmunity accompanied by elevated numbers of double-negative (DN) T cells (T-cell receptor...