Turnover Modeling of Non-Esterified Fatty Acids in Rats after Multiple Intravenous Infusions of Nicotinic Acid

• 主要な著者: Christine Isaksson (著者), Johan Gabrielsson (著者), Kristina Wallenius (著者), Lambertus A. Peletier (著者), Helena Toreson (著者)
• フォーマット: 図書
• 出版事項: SAGE Publishing, 2009-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The objective of this investigation was to use a pharmacokinetic (PK)/pharmacodynamic (PD) approach to describe and evaluate a PK model of nicotinic acid (NiAc) in guinea pigs and a PD feedback model of changes in non-esterified fatty acid (NEFA) concentrations in rats following multiple intravenous...