Rhodium-Catalyzed Ortho-Vinylation of 2-Arylpyridines and Its Application in the Total Synthesis of Palmatine

• Main Authors: Shan Lv (Author), Ruifang Nie (Author), Lingmei Guo (Author), Yang Zheng (Author), Yanzhao Liu (Author), Li Guo (Author), Yong Wu (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An efficient protocol by Rh-catalyzed direct C-H vinylation of 2-arylpyridines with a commercially available and air-stable potassium vinyl donor has been developed. This method affords the corresponding pyridinyl styrene derivative with moderate to excellent yields under mild conditions, which is e...