Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics

• Үндсэн зохиолчид: Ida Lin (Зохиогч), Peter B. Rupert (Зохиогч), Kristina Pilat (Зохиогч), Raymond O. Ruff (Зохиогч), Della J. Friend (Зохиогч), Man Kid Chan (Зохиогч), Midori Clarke (Зохиогч), Benjamin G. Hoffstrom (Зохиогч), Jane Carter (Зохиогч), Soheil Meshinchi (Зохиогч), Ashok D. Bandaranayake (Зохиогч), Christopher Mehlin (Зохиогч), James M. Olson (Зохиогч), Roland K. Strong (Зохиогч), Colin E. Correnti (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin's precise biological function and overall structure remain undefined. Antibodies targetin...