Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics

• Main Authors: Ida Lin (Author), Peter B. Rupert (Author), Kristina Pilat (Author), Raymond O. Ruff (Author), Della J. Friend (Author), Man Kid Chan (Author), Midori Clarke (Author), Benjamin G. Hoffstrom (Author), Jane Carter (Author), Soheil Meshinchi (Author), Ashok D. Bandaranayake (Author), Christopher Mehlin (Author), James M. Olson (Author), Roland K. Strong (Author), Colin E. Correnti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin's precise biological function and overall structure remain undefined. Antibodies targetin...