Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain

• Main Authors: Yuko Takayasu (Author), Junko Nakaki (Author), Toshiyuki Kawasaki (Author), Ken Koda (Author), Yukio Ago (Author), Akemichi Baba (Author), Toshio Matsuda (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain. Edaravone at 10 - 100 µM inhibited Ca2+- and H2O2-induced swelling...