An Injectable Click-Crosslinked Hydrogel that Prolongs Dexamethasone Release from Dexamethasone-Loaded Microspheres

• Main Authors: Ji Yeon Heo (Author), Jung Hyun Noh (Author), Seung Hun Park (Author), Yun Bae Ji (Author), Hyeon Jin Ju (Author), Da Yeon Kim (Author), Bong Lee (Author), Moon Suk Kim (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our purpose was to test whether a preparation of injectable formulations of dexamethasone (Dex)-loaded microspheres (Dex-Ms) mixed with click-crosslinked hyaluronic acid (Cx-HA) (or Pluronic (PH) for comparison) prolongs therapeutic levels of released Dex. Dex-Ms were prepared using a monoaxial-nozz...