The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

• Main Authors: Alessandro Bonardi (Author), Silvia Bua (Author), Jacob Combs (Author), Carrie Lomelino (Author), Jacob Andring (Author), Sameh Mohamed Osman (Author), Alessandra Toti (Author), Lorenzo Di Cesare Mannelli (Author), Paola Gratteri (Author), Carla Ghelardini (Author), Robert McKenna (Author), Alessio Nocentini (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human (h) carbonic anhydrase (CAs, EC 4.2.1.1) isoforms IX and XII were recently confirmed as anticancer targets against solid hypoxic tumours. The "three-tails approach" has been proposed as an extension of the forerunner "tail" and "dual-tail approach" to fully exploi...