Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of <i>Salmonella</i> Serovars

• Main Authors: Aqsa Shaheen (Author), Anam Tariq (Author), Mazhar Iqbal (Author), Osman Mirza (Author), Abdul Haque (Author), Thomas Walz (Author), Moazur Rahman (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position and type of the mutation (s) in the QRDRs, bacter...