Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors

• मुख्य लेखकों: Francesca Lazzara (लेखक), Maria Consiglia Trotta (लेखक), Chiara Bianca Maria Platania (लेखक), Michele D'Amico (लेखक), Francesco Petrillo (लेखक), Marilena Galdiero (लेखक), Carlo Gesualdo (लेखक), Settimio Rossi (लेखक), Filippo Drago (लेखक), Claudio Bucolo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial cells (HRECs). We investigated in...