Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects

Inhibition of the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) represents a potential mechanism for improving pain conditions. ASP3662 is a potent and selective inhibitor of 11β‐HSD1. Two phase I clinical studies were conducted to assess the safety, tolerability, pharmacokinetics (PKs),...

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主要な著者: Susan Bellaire (著者), Mark Walzer (著者), Tianli Wang (著者), Walter Krauwinkel (著者), Nancy Yuan (著者), Gerard J. Marek (著者)
フォーマット: 図書
出版事項: Wiley, 2019-05-01T00:00:00Z.
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