Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects

• Main Authors: Susan Bellaire (Author), Mark Walzer (Author), Tianli Wang (Author), Walter Krauwinkel (Author), Nancy Yuan (Author), Gerard J. Marek (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2019-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Inhibition of the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) represents a potential mechanism for improving pain conditions. ASP3662 is a potent and selective inhibitor of 11β‐HSD1. Two phase I clinical studies were conducted to assess the safety, tolerability, pharmacokinetics (PKs),...