Neural crest-specific loss of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction and disordered breathing, modeling obstructive sleep apnea

• Main Authors: Pranidhi Baddam (Author), Vivian Biancardi (Author), Daniela M. Roth (Author), Farah Eaton (Author), Claudine Thereza-Bussolaro (Author), Rupasri Mandal (Author), David S. Wishart (Author), Amy Barr (Author), Joanna MacLean (Author), Carlos Flores-Mir (Author), Silvia Pagliardini (Author), Daniel Graf (Author)
• Format: Book
• Published: The Company of Biologists, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pediatric obstructive sleep apnea (OSA), a relatively common sleep-related breathing disorder affecting ∼1-5% of children, is often caused by anatomical obstruction and/or collapse of the nasal and/or pharyngeal airways. The resulting sleep disruption and intermittent hypoxia lead to various systemi...