Modeling human T1D-associated autoimmune processesBox 1. Potential applications of models to understand the immune processes leading to human T1D.Box 2. Potential applications of models to evaluate treatments for human T1D.

• Main Authors: Mohsen Khosravi-Maharlooei (Author), Rachel Madley (Author), Chiara Borsotti (Author), Leonardo M.R. Ferreira (Author), Robert C. Sharp (Author), Michael A. Brehm (Author), Dale L. Greiner (Author), Audrey V. Parent (Author), Mark S. Anderson (Author), Megan Sykes (Author), Remi J. Creusot (Author)
• Formato: Livro
• Publicado em: Elsevier, 2022-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by impaired immune tolerance to β-cell antigens and progressive destruction of insulin-producing β-cells. Animal models have provided valuable insights for understanding the etiology and pathogenesis of this disease, but they f...