Effects of antibiotic antitumor drugs on nucleotide levels in cultured tumor cells: an exploratory method to distinguish the mechanisms of antitumor drug action based on targeted metabolomics

• Главные авторы: Fang Wang (Автор), Xi Liu (Автор), Cuichai Liu (Автор), Zheng Liu (Автор), Lixin Sun (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2015-05-01T00:00:00Z.
• Предметы: article
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Nucleotide pools in mammalian cells change due to the influence of antitumor drugs, which may help in evaluating the drug effect and understanding the mechanism of drug action. In this study, an ion-pair RP-HPLC method was used for a simple, sensitive and simultaneous determination of the levels of...