Imipramine is an orally active drug against both antimony sensitive and resistant Leishmania donovani clinical isolates in experimental infection.

• Main Authors: Sandip Mukherjee (Author), Budhaditya Mukherjee (Author), Rupkatha Mukhopadhyay (Author), Kshudiram Naskar (Author), Shyam Sundar (Author), Jean Claude Dujardin (Author), Anjan Kumar Das (Author), Syamal Roy (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: In an endeavor to find an orally active and affordable antileishmanial drug, we tested the efficacy of a cationic amphiphilic drug, imipramine, commonly used for the treatment of depression in humans. The only available orally active antileishmanial drug is miltefosine with long half lif...