Simultaneous Quantification and Pharmacokinetic Characterization of Doxapram and 2-Ketodoxapram in Porcine Plasma and Brain Tissue

• Main Authors: Manuel Kraft (Author), Kathrin I. Foerster (Author), Felix Wiedmann (Author), Max Sauter (Author), Amelie Paasche (Author), Pablo L. Blochberger (Author), Baran Yesilgöz (Author), Yannick L'hoste (Author), Norbert Frey (Author), Walter E. Haefeli (Author), Jürgen Burhenne (Author), Constanze Schmidt (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atrial fibrillation (AF) is an arrhythmia associated with an increased stroke risk and mortality rate. Current treatment options leave unmet needs in AF therapy. Recently, doxapram has been introduced as a possible new option for AF treatment in a porcine animal model. To better understand its pharm...