Synthesis, cytotoxicity study of novel bisacridine derivatives and their interaction with c-myc promoter G-quadruplex/i-motif

• Main Authors: Bing Shu (Author), Wang-liang Chen (Author), Jia-lin Song (Author), Shen Fang (Author), Jiong-bang Li (Author), Shang-shi Zhang (Author)
• Format: Book
• Published: KeAi Communications Co., Ltd., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To synthesize novel bisacridine derivatives A1-A4 and study cytotoxicity and their interaction with c-myc G-quadruplex/i-motif DNA. Method: Bisacridines A1-A4 were synthesized according to the conventional reaction method. Fluorescence resonance energy transfer (FRET) melting assay, Surfa...