Synthesis, cytotoxicity study of novel bisacridine derivatives and their interaction with c-myc promoter G-quadruplex/i-motif

• Hoofdauteurs: Bing Shu (Auteur), Wang-liang Chen (Auteur), Jia-lin Song (Auteur), Shen Fang (Auteur), Jiong-bang Li (Auteur), Shang-shi Zhang (Auteur)
• Formaat: Boek
• Gepubliceerd in: KeAi Communications Co., Ltd., 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: To synthesize novel bisacridine derivatives A1-A4 and study cytotoxicity and their interaction with c-myc G-quadruplex/i-motif DNA. Method: Bisacridines A1-A4 were synthesized according to the conventional reaction method. Fluorescence resonance energy transfer (FRET) melting assay, Surfa...