PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

• Hauptverfasser: Wei Li (Verfasst von), Lu Xue (Verfasst von), Changsi Peng (Verfasst von), Ping Zhao (Verfasst von), Yongbo Peng (Verfasst von), Weiwei Chen (Verfasst von), Wenyi Wang (Verfasst von), Jinhua Shen (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2023-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. However, the study of PP121 in pulmonary diseases is still limited. Her...