PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

• मुख्य लेखकों: Wei Li (लेखक), Lu Xue (लेखक), Changsi Peng (लेखक), Ping Zhao (लेखक), Yongbo Peng (लेखक), Weiwei Chen (लेखक), Wenyi Wang (लेखक), Jinhua Shen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2023-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. However, the study of PP121 in pulmonary diseases is still limited. Her...