PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

• Autores principales: Wei Li (Autor), Lu Xue (Autor), Changsi Peng (Autor), Ping Zhao (Autor), Yongbo Peng (Autor), Weiwei Chen (Autor), Wenyi Wang (Autor), Jinhua Shen (Autor)
• Formato: Libro
• Publicado: BMC, 2023-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. However, the study of PP121 in pulmonary diseases is still limited. Her...