Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension

• Main Authors: Yinan Shi (Author), Chenxin Gu (Author), Tongtong Zhao (Author), Yangfan Jia (Author), Changlei Bao (Author), Ang Luo (Author), Qiang Guo (Author), Ying Han (Author), Jian Wang (Author), Stephen M. Black (Author), Ankit A. Desai (Author), Haiyang Tang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rationale: Enhanced proliferation and distal migration of human pulmonary arterial smooth muscle cells (hPASMCs) both contribute to the progressive increases in pulmonary vascular remodeling and resistance in pulmonary arterial hypertension (PAH). Our previous studies revealed that Rictor deletion,...