Suppressive Effects of Cooling Compounds Icilin on Penicillin G-Induced Epileptiform Discharges in Anesthetized Rats

• Main Authors: Hiroshi Moriyama (Author), Sadahiro Nomura (Author), Hiroyuki Kida (Author), Takao Inoue (Author), Hirochika Imoto (Author), Yuichi Maruta (Author), Yuichi Fujiyama (Author), Dai Mitsushima (Author), Michiyasu Suzuki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

More than 30% of patients with epilepsy are refractory and have inadequate seizure control. Focal cortical cooling (FCC) suppresses epileptiform discharges (EDs) in patients with refractory focal cortical epilepsy. However, little is known about the mechanism by which FCC inhibits seizures at 15°C,...