Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps

In discovery of novel HDAC inhibitory with anticancer potency, pharmacophores of phenanthridine were introduced to the structure of HDAC inhibitors. Fatty and aromatic linkers were evaluated for their solubility and activity. Both enzyme inhibitory and in vitro antiproliferative (against U937 cells)...

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Main Authors: Wenli Fan (Author), Lin Zhang (Author), Xuejiang Wang (Author), Haiyong Jia (Author), Lei Zhang (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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