Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice

• 主要な著者: Satoko Shimazu-Kuwahara (著者), Norio Harada (著者), Shunsuke Yamane (著者), Erina Joo (著者), Akiko Sankoda (著者), Timothy J. Kieffer (著者), Nobuya Inagaki (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2017-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake and storage. GIP receptor knockout mice are protected from diet induced weight gain and thus GIP antagonists have been proposed as a treatment for obesity. In this study, we assessed t...