Development and Evaluation of Solid Dispersion-Based Sublingual Films of Nisoldipine

• Main Authors: Yahya Alhamhoom (Author), Abhay Sharma (Author), Shivakumar Hagalavadi Nanjappa (Author), Avichal Kumar (Author), Anas Alshishani (Author), Mohammed Muqtader Ahmed (Author), Syeda Ayesha Farhana (Author), Mohamed Rahamathulla (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nisoldipine (NIS) is a calcium channel blocker that exhibits poor bioavailability (~5%) due to low aqueous solubility and presystemic metabolism in the gut wall. In this context, the present work aimed to develop NIS solid dispersion (NISSD)-based sublingual films using solvent casting technique to...