Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex

• Main Authors: Keisuke Obara (Author), Saki Horiguchi (Author), Toma Shimada (Author), Takumi Ikarashi (Author), Fumiko Yamaki (Author), Kazuhiro Matsuo (Author), Takashi Yoshio (Author), Yoshio Tanaka (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat dementia. We investigated the inhibitory effec...